gynecology
Conditions
Interventions
control group:no transversus abdominis plane block
group R:transversus abdominis plane block with 0.25% ropivacaine
group R+D1:transversus abdominis plane block with 0.2% ropivacaine and 0.25 ug/kg dexmedetomidine
group R+D2:transversus abdominis plane block with 0.2% ropivacaine and 0.5 ug/kg dexmedetomidine
group R+D3:transversus abdominis plane block with 0.2% ropivacaine and 1.0 ug/kg dexmedetomidine
Sponsors
The People's Hospital, China Three Gorges University; The First Hospital of Yichang City
Eligibility
Sex/Gender
Female
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Aged 18-65 years old; American Society of Anesthesiologists (ASA) physical status classification, class I or II;operation time is within 3 hours; be able to cooperate to complete the test; laparoscopic gynecologic nonmalignant tumor surgery patients under the general anesthesia.
Exclusion criteria
Exclusion criteria: Combined with malignant tumor,hypertension, diabetes,heart disease, adrenal gland diseases and severe hepatic and renal dysfunction; combined with chronic pain and bradycardia; long-term use of corticosteroids, analgesics, adrenergic agonists and antagonists; alcohol, nicotine and opioid dependence; local anesthetics allergy; turn to laparotomy; BMI = 35 kg/m2; fail to transversus abdominis plane block.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| plasma cortisol;plasma epinephrine;plasma norepinephrine;blood glucose;blood insulin;plasma IL-6;VAS scores in rest;VAS scores during coughing;sedation scores;total dosage of analgesic; | — |
Secondary
| Measure | Time frame |
|---|---|
| sevoflurane dosage;propofol dosage;sufentanil dosage;incidence of adverse reactions; | — |
Countries
China
Contacts
Public ContactQin Zhaojun
The People's Hospital, China Three Gorges University; The First Hospital of Yichang City
Outcome results
None listed