Alzheimer's disease
Conditions
Interventions
AD combined intervention group:Folic acid, 1.2mg /day, Vitamin B12 50µg /day, oral, six months
AD placebo group:placeboes of simulated folic acid, 3#/day,placebo of vitamin B12 2#/day,oral, six months
Sponsors
Tianjin Medical University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Aged 40–90 years; Hachinski Ischemic Scale score <4; Hamilton Depression Rating Scale score <7.0; MMSE score 3.0–26.0 points; activities of daily living (ADL) score =22.0; cerebral computed tomography or magnetic resonance imaging showing varying degrees of ventricular dilatation; medial temporal lobe and hippocampal atrophy, widening of the cerebral sulci, and other cortical atrophy.
Exclusion criteria
Exclusion criteria: Patients who had encephalopathy, which can appear clinically similar to AD. Patients who had taken the prescribed daily intake of vitamins B, C, or E within the month before baseline and those who had regularly taken B vitamin supplements within the 6 months before baseline.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| serum folate;serum vitaminB12;mini-mental state examination;Alzheimer's Disease Assessment Scale-cognitive;Alzheimer’s Disease Co-operative Study ADL Scale; | — |
Secondary
| Measure | Time frame |
|---|---|
| tumor necrosis factor;Interleukin 6 (IL-6);Interleukin 6;plasma Aß40;plasma Aß42;S-adenosylmethionine;S-adenosylhomocysteine;plasma homocysteine; | — |
Countries
China
Contacts
Public ContactGuowei Huang
Tianjin Medical University
Outcome results
None listed