latent tuberculosis
Conditions
Interventions
negative control group:without any anti-tuberculosis drugs
isoniazid group:oral take isoniazid for 6 months
isoniazid + rifampicin + pyrazinamide + ethambutol group :isoniazid + rifampicin + pyoral take razinamide + ethambutol for 2 months
isoniazid+rifampicin group:oral take isoniazid+ rifampicin for 4 months
isoniazid+rifampicin+pyrazinamide group:isoniazid+rifampicin+pyrazinamide for 2 months
Sponsors
Respiratory Department, Fuling Central Hospital, Fuling District, Chongqing
Eligibility
Sex/Gender
All
Age
20 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. The population has long-term contact with patients of active tuberculosis for one year or longer, including medical staff, family members of patients or population with low autoimmunity (such as diabetes or pneumonoconiosis patients); 2. Aged 20-70 years; 3. Diagnosis criteria of latent tuberculosis: PPD showed strong positive (+++) or T-SPOT showed positive (+).
Exclusion criteria
Exclusion criteria: 1. patients who diagnosed or suspected with active tuberculosis, including with following-up criteria: image show tuberculosis characteristic changes such as nodosity or fabric like shadows; relevant evidence of acid-fast bacillus were found in sputum or other body fluid species. 2. patients with obvious abnormal function of liver or kidney; patients have obvious disorder of coagulation; 3. Patients have disorder of vision or audition; 4. Grade 3-4 cardiac function, serious hypertension (blood pressure was still higher than 160/100mmHg after effective decompaction treatment), serious cardiac arrhythmias, aortic aneurysm, epilepsy or hypertension intracranial; 5. Patients with history of active tuberculosis; 6. refuse to anticipate this clinical research.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Rate of active tuberculosis; | — |
Secondary
| Measure | Time frame |
|---|---|
| Rate of adverse effect; | — |
Countries
China
Contacts
Public ContactLisa Kuang
Fuling Central Hospital, Chongqing
Outcome results
None listed