carotid artery stenosis
Conditions
Interventions
CEA group:On the basis of regular medical treatment of internal medicine, the patients were given CEA treatment. The CEA operation would be performed under general anesthesia, with shunt or artery pat
CSA group:On the basis of regular medical treatment of internal medicine, the patients were given CSA treatment. The CSA treatment would be performed under local anesthesia, with distal filter protect
Sponsors
Renji Hospital (South Campus), Shanghai Jiaotong University School of Medicine
Eligibility
Sex/Gender
All
Age
50 Years to 80 Years
Inclusion criteria
Inclusion criteria: Clnincal setting: 1. In half year, patients with amaurosis, ischemic stroke or transient ischemic attack caused by internal carotid artery stenosis; 2. MRS score<3; 3. Male and female aged 50-80 years; 4. To be willing and able to provide written informed consent/assent for the trial. Vascular conditions: According to cerebral angiography result,the degree of carotid artery stenosis is 50-99%, and the stenosis location is in the common carotid artery, carotid bifurcation or internal carotid artery. Neurosurgeon believe that two surgical methods, CEA and CSA are appropriate.
Exclusion criteria
Exclusion criteria: Clnincal setting: 1. Intracranial hemorrhage in 3 months; 2. Hypertension is not effectively controlled; 3. Pregnant or lactating patients; 4. Accompany by intracranial vascular malformations or aneurysms at the same time; 5. Accompany by other serious diseases, the estimated survival time is less than 2 years; 6. Have coagulation disorders; 7. Have contraindication of heparin, aspirin and clopidogrel; 8. Have contraindication of contrast medium; 9. Have another surgical plan. Vascular conditions: 1. Common carotid artery or carotid artery occlusion; 2. Carotid stenosis due to external compression; 3. Carotid stenosis due to arterial dissection; 4. Restenosis after surgery or stenting; 5. Carotid stenosis induced by radiation; 6. Carotid stenosis due to the dysplasia of muscular fibers; 7. Active thrombus; 8. Simultaneous presence of intracranial artery stenosis or contralateral carotid stenosis. In addition, 1) patients who were participating in other clinical trials; 2) the researchers considered other reasons not suitable for clinical trials.
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| Carotid ultrasound examination;Cerebral angiography; | — |
Primary
| Measure | Time frame |
|---|---|
| Neurological assessment NIHSS score;High resolution multi modality MR examination to assess the carotid plaques and brain; | — |
Countries
China
Contacts
Public ContactDai Jiong
Renji Hospital (South Campus), Shanghai Jiaotong University School of Medicine
Outcome results
None listed