Chronic suppurative otitis media and middle ear cholesteatoma
Conditions
Interventions
treatment group:Bone surface covering tissue regeneration membrane
control group:conventional surgical treatment
Sponsors
Chinese Academy of Medical Sciences & Peking Union Medical College Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Male and female aged 18-70 years; 2. The patient with chronic suppurative otitis media and/or middle ear cholesteatoma; 3. The patient need to open mastoidotympanectomy; 4. The patient hadn't to participate in other clinical trial in three months before the start; 5. After obtaining informed, voluntary and signed the informed consent.
Exclusion criteria
Exclusion criteria: 1. The patient need to shrinkage cavity mastoidotympanectomy; 2. Allergy of collagen products; 3. The patient with mental illness or mental abnormal; 4. The patient is suffering from acute or chronic respiratory infection; 5. The patient with severe liver and kidney dysfunction or metabolic syndrome or serious systemic diseases such as malignant tumor; 6. During pregnancy or breastfeeding women or plan in the three months of pregnancy patient; 7. Nearly a month general continuous use hormone; 8. Long-term use of immune inhibitor; 9. Patient with diabetes; 10. Patient with surgical contraindication; 11. Other researchers determine does not comply with the conditions of patients.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| dry ear rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| dry ear rate;Air-bone gap that Postoperative and preoperative differential;time of surgery;number of dressing change; | — |
Countries
China
Contacts
Public ContactZhiqiang Gao
Chinese Academy of Medical Sciences and Peking Union Medical College Hospital
Outcome results
None listed