HBV-related chronic-on-acute liver failure
Conditions
Interventions
entecavir group:oral entecavir
Jieduzhuyu and entecavir group:Jieduzhuyu decotion enema and oral entecavir
Xiaohuang decotion, Jieduzhuyu and entecavir group:Oral Xiaohuang decotion, Jieduzhuyu decotion enema and oral entecavir
Sponsors
Shanghai Public Health Clinical Center, Fudan University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. aged 18~65 years old; 2. patients diagnosed as HBV-related chronic-on-acute liver failure of early-middle satge; 3. Signed informed consent.
Exclusion criteria
Exclusion criteria: 1. Patients with gastrointestinal bleeding and/or hepatic encephalopathy over level 3, those who failed to tolerate oral TCM decotion and/or TCM enema; 2. Patients with severe cardiovascular diseases, kidney diseases, hematologic diseases, lung diseases (asthma, COPD), autoimmnue diseases or other conditions influencing survival including cancer or AIDS; 3. Women who are breastfeeding, pregnancy or are preparing for pregnancy; 4. Patients without capacity for civil conduct or limited capacity; 5. Patients who have a history of alcohol abuse and/or drug abuse; 6. Those who are allergic to the constituents of the test drug and those who are allergic; 7. Patients who have participated in other clinical trials in the past 3 months; 8. Those who are not appropriate to participate in the trial evaluated by researchers.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Overall Survival; | — |
Secondary
| Measure | Time frame |
|---|---|
| liver function tests;prothrombin time;prothrombin activity; | — |
Countries
China
Contacts
Public ContactXiaorong Chen
Shanghai Public Health Clinical Center, Fudan University
Outcome results
None listed