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Sevoflurane Versus PRopofol Combined with Remifentanil Anesthesia Impact on Postoperative Neurological Function in Supratentorial Gliomas (SPRING)

Inhalational versus intravenous anesthesia impact on neurological function and neurocognition in patients with supratentorial gliomas

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR-IOR-16009177
Enrollment
Unknown
Registered
2016-09-08
Start date
2018-05-28
Completion date
Unknown
Last updated
2018-05-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Supratentorial Glioma

Interventions

TIVA:Propofol combined with Remifentanil
Inhalational:Sevoflurane combined with Remifentanil

Sponsors

Beijing Tiantan Hospital, Capital Medical University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 65 Years

Inclusion criteria

Inclusion criteria: 1. Supratentorial glioma diagnosed by MRI for elective craniotomy; 2. New and/or recurrent intracranial glioma; 3. Aged 18 to 65 years; 4. ASA I to II; 5. Glasgow score 15; 6. Without preoperative symptomatic elevated ICP; 7. Institutional approval and informed consent.

Exclusion criteria

Exclusion criteria: 1. Unable to comprehend and cooperate with the neurologic examination; 2. Emergency craniotomy or changed into emergency from elective craniotomy; 3. With traumatic brain injury, hemorrhage or cerebral vascular diseases; 4. Prolonged emergence, mechanical ventilation and sedation dependence due to definite reason eg. surgery itself, tumor location etc.; 5. Uncontrolled hypertension and severe heart diseases that impair cardiac function (New York Heart Association Functional Classification=III); 6. History of related anesthetic allergy; 7. With hypothalamus dysfunction; 8. Severe endocrine system dysfunction that impair metabolic index; 9. Impaired mental status; 10. Drug and/or alcohol abuse; 11. Pregnant and/or lactation period woman; 12. Accept radiotherapy and/or chemotherapy before surgery; 13. With neuromuscular diseases; 14. With infectious and/or immune diseases that have positive biomarker(s).

Design outcomes

Primary

MeasureTime frame
NIH Stroke Scale;Modified NIH Stroke Scale;Mini–Mental State Examination;—

Secondary

MeasureTime frame
Head MRI;Pathological diagnosis;Blood pressure;heart rate;SpO2;Depth of Anesthesia;brain relaxation;Anesthesia Recovery Quality;Visual Analog Scale for postoperative pain;postoperative complications;Anesthesia expenses;Stress and immune reaction biomarker;QoR-40 Quality of Recovery from Anesthesia;—

Countries

China

Contacts

Public ContactNan LIN

Beijing Tiantan Hospital, Capital Medical University

linnan127@163.com+86 10-13810108927

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 18, 2026