Hysteromyoma,Adenomyosis
Conditions
Interventions
Group M:Methylprednisolone before surgery
Group P:Parecoxib Sodium after surgery
Group O:No measure of anti-inflammatory
Sponsors
Xuanwu Hospital of CCMU
Eligibility
Sex/Gender
Female
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. American Society of Anesthesiologists (ASA) physical status I~II; 2. Aged 18~65 years; 3. Patients scheduled for laparoscopic assisted vaginal hysterectomy in Xuanwu Hospital.;Inclusion criteria: 1. American Society of Anesthesiologists (ASA) physical status I~II; 2. Aged 18~65 years; 3. Patients scheduled for laparoscopic assisted vaginal hysterectomy in Xuanwu Hospital.
Exclusion criteria
Exclusion criteria: 1. The patient's too old or too young, ASA physical status =III; 2. Significant renal impairment(creatinine>177µmol/L); Congestive heart-failure (NYHA status IV) or other severe systemic disease; 3. Cerebral vascular disease within 6 months, include cerebral hemorrhage and infraction, or over 6 months but with neurological sequelae; 4. Patients with severe malnourishment or deficiency of hormone secretion; 5. Patients with smoking history; 6. Acute trauma or inflammatory disease; 7. Patients with diseases which would lead to high infalmmatory factors, such as infection, cancer etc.; 8. History of drug and alcohol abuse; 9. Patients with contraindication of using parecoxib sodium, methylprednisolone or oxycodone; 10. Patients who disagree to participate in the research.;Exclusion criteria: 1. The patient's too old or too young, ASA physical status =III; 2. Significant renal impairment(creatinine>177µmol/L); Congestive heart-failure (NYHA status IV) or other severe systemic disease; 3. Cerebral vascular disease within 6 months, include cerebral hemorrhage and infraction, or over 6 months but with neurological sequelae; 4. Patients with severe malnourishment or deficiency of hormone secretion; 5. Patients with smoking history; 6. Acute trauma or inflammatory disease; 7. Patients with diseases which would lead to high infalmmatory factors, such as infection, cancer etc.; 8. History of drug and alcohol abuse; 9. Patients with contraindication of using parecoxib sodium, methylprednisolone or oxycodone; 10. Patients who disagree to participate in the research.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| NRS score;Duration of postoperative pain;;NRS score;Duration of postoperative pain; | — |
Secondary
| Measure | Time frame |
|---|---|
| TNF-a;C reactive protein;;TNF-a;C reactive protein; | — |
Countries
China
Contacts
Public ContactWANG TIANLONG;WANG TIANLONG ;
Xuanwu Hospital of CCMU;Xuanwu Hospital of CCMU
Outcome results
None listed