Cervical cancer
Conditions
Interventions
Low-dose group, high-dose group:Different doses
Sponsors
The Third Affiliated Hospital, Harbin Medical University
Eligibility
Sex/Gender
Female
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1) volunteered for the experiment, and signed informed consent; 2) the age of 18 or more and hospitalized patients under the age of 70 or less, men and women not limited; 3) is expected to in-hospital time 24 hours or more; 4) undergoing elective cervical cancer surgery under general anesthesia laparotomy, and expected postoperative patients require 24 hours morphine analgesia.
Exclusion criteria
Exclusion criteria: 1) known patients allergic to or arginine ibuprofen, or aspirin, cox-2 inhibitors and other non-steroidal anti-inflammatory drugs (nsaids) after asthma, urticaria or allergic reaction of the patients; 2) higher than that of patients at risk of blood, including congenital and platelet function in patients with abnormal bleeding disease patients or patients with the clinical significance of any active bleeding; 3) has a history of asthma or heart failure patients; 4) with severe patients at risk of cardiovascular disease or aggravating; 5) because of serious head trauma, leading to the hospital, or preoperative had intracranial surgery in a month or, or a history of stroke patients with cerebral arteriovenous malformations, cerebral aneurysm patients; 6) preoperative six weeks with peptic ulcer or has a history of gastrointestinal bleeding and need treatment; 7) preoperative is longer than a month of moderately severe pain, the spirit of the bowel, depression and multiple operation history; 8) are currently using warfarin or lithium or combination of angiotensin converting enzyme inhibitors and diuretics in patients; 9) preoperative 6 h used acetaminophen, or within 24 h used non-steroidal anti-inflammatory drugs patients; 10) preoperative within 24 h used other analgesics, and muscle relaxants. 11) has obvious clinical significance of patients with anemia (Hb < 90 g/L); 12) patients with platelet count of 80 x 10^9/L or less; 13) patients of liver and kidney dysfunction (ALT and AST 1.5 times greater than the upper limit of normal, creatinine is greater than the upper limit of normal); 14) weight of 40 kg or less of patients; 15) preexisting dependence on narcotic drugs or known for patients with opioid tolerance; 16) pregnancy or lactation women; 17) of patients with abnormal mental system history and received organ transplant patients; Within 3 month before the screening 18) patients participated in any other clinical trials of patients; 19) the researchers believe that there may be an increased risk subjects or interfere with the clinical trials performed any situation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Morphine consumption; | — |
Countries
China
Contacts
Public ContactXintong Liu
The Third Affiliated Hospital, Harbin Medical University
Outcome results
None listed