acute pancreatitis
Conditions
Interventions
NTF within 72h:naso-jejunum tube feeding
NTF after 72h:naso-jejunum tube feeding
Sponsors
Chengdu Military General Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. All cases should be in accordance with the SAP diagnostic criteria for classification of acute pancreatitis in Atlanta (2012); 2. Patients aged from 18 to 65 years old; 3. The onset time is less than 72 hours till the time of radomization, admission without nutritional support treatment; 4. Patients APACHE II score is greater than or equal to eight pointsor C-reactive protein is greater than or equal to 150mg/dlor BalthazarCT score is greater than or equal to four points within 48 hours after onset; 5. Patients and their family members volunteered to the object of the observation and fill in the informed consent.
Exclusion criteria
Exclusion criteria: 1. Patients with malignant tumor, chronic organ dysfunction and other severe diseases were excluded; 2. Patients with gastrointestinal bleeding, intestinal obstruction and other digestive tract diseases were excluded; 3. Exclusion of pregnancy SAPtraumatic SAP patients, post-ERCP AP; 4. Exclusion of SAP patients who were unable to be placed in the jejunum nutrition tube, or who were unable to tolerate long-term placement of the jejunum nutrition tube; 5. Patients with open abdominal surgery before admission and after admission were excluded; 6. Gastric retention presenting from clinical symptom, physical signs or abdominal CT examination; 7. Patients with drug abuse, psychinosis; 8. Allergy to the EN formula; 9. the intra-abdominal pressure is greater than or equal to 15mmHg; 10. hemodynamic instability.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| peri-pancreatic infection;Ascites bacterial culture positive;number of organ failure; | — |
Secondary
| Measure | Time frame |
|---|---|
| DAO;D-lactate;endotoxin;PCT;TNF-alfa;IL-1;IL-6;MTL;VIP;prealbumin;RBP;transferrin;hemoglobin;AC;TSF;AMC;the power of gripping;length of ICU stay;hospital stay;fee;intra-abdominal pressure;bowel sound;time interval from onset to fart;time interval from EN start to target;diarrhea;conspitation;hemorrhage of digestive tract;nausea;vomit;obstruction;dislodging;Abdominal pain score; | — |
Countries
China
Contacts
Public ContactLi-Jun Tang
Chengdu Military General Hospital
Outcome results
None listed