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A prospective randomized controlled trial of PGS assisted reproduction for elder patient by High-throughput sequencing

A prospective randomized controlled trial of PGS assisted reproduction for elder patient by High-throughput sequencing

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR-IOR-16008953
Enrollment
Unknown
Registered
2016-08-02
Start date
2016-09-01
Completion date
Unknown
Last updated
2017-04-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

infertility

Interventions

Sponsors

Reproductive and genetic Hospital of Citic- Xiangya
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
37 Years to 44 Years

Inclusion criteria

Inclusion criteria: (1) Premenopausal females, aged 37 to 44 years; (2) Have given birth to a health baby; (3) Bilateral ovaries; (4) AFC=10, and AMH=2.0 ng/ml.

Exclusion criteria

Exclusion criteria: (1) Endometriosis disease; (2) Intrauterine adhesions history; intrauterine membrane polyp, tuberculosis and inflammation; (3) Uterine malformation, multiple uterine myoma, uterine intramural myoma >3cm, submucous myoma; (4) Unprocessed hydrosalpinx; (5) Adverse reproductive history; greater than or equal to 2 times history of unexplained abortion; (6) Chromosomal abnormalities or other genetic disease; (7) Infertility caused by male factors, such as puncture testicular, SRT did not see the class A and class B sperm; (8) Without high quality embryos in past COH cycles; (9) Patients with poor ovarian response, the standard of poor ovarian response accords with Bolognacriteria standard, that is at least meet 2 among the following 3: 1) Elder years (=40 years) or have other known inherited or acquired risk factors that may reduce follicle; 2) History of cancellation of the cycles because of less than 3 follicular development, or history of egg number less than 4 after at least using FSH150IU once a day; 3) Ovarian reserve function test abnormalities, including sinus follicle number less than 5-7 (AFC) or AMH less than 0.5 to 1.1 ng/ml.

Design outcomes

Primary

MeasureTime frame
live birth rate;

Secondary

MeasureTime frame
cancellation rate;pregnancy rate;miscarriage rate;

Countries

China

Contacts

Public ContactYi Tang

Reproductive & Genetic Hospital of CITIC-XIANGYA, Changsha, Hunan

cstangyi@sina.com+86 731 85355100

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026