lung damage
Conditions
Interventions
driving pressure guided PEEP setting:change PEEP based on driving pressure
Conventional fixed PEEP:Standard fixed PEEP at 6 cmH2O
Sponsors
Xinhua Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China.
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: ASA II-III status patients scheduled for open upper abdominal surgery expected to last more than 2 h under general anesthesia, who had intermediate-to-high risk of developing PPCs (as defined by the ARISCAT score), and patients aged 18-80 yrs, and Body-mass index (BMI) less than 35 kg/m2..
Exclusion criteria
Exclusion criteria: 1.Patients with a history of upper respiratory tract or pulmonary infection within 4 weeks before surgery; 2.Pleural effusion; 3.Chest- and lung-associated diseases; 4.Neuromuscular dysfunction; 5.Serious cardiovascular, lung, kidney, and hematopoietic diseases;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of clinically significent postoperative pulmonary complications ; | — |
Secondary
| Measure | Time frame |
|---|---|
| 30-day mortality;length of hospital stay;ICU occupancy rate;severity of postoperative pulmonary complications;Incidence of severe postoperative pulmonary complications;Severity of atelectasis;Severity of pleural effusion; | — |
Countries
China
Contacts
Public ContactXueyin Shi
Xinhua Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China.
Outcome results
None listed