unlimited
Conditions
Interventions
Dex group:receive dexmedetomidine sedation
Pro group:receive propofol sedation
Sponsors
the First Affiliated Hospital of Sun Yat-Sen University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: Aged 18 or over 18 years old, male or female; conscious;receiving assisted ventilation and requiring sedative and analgesic medication; expected to stay in ICU for more than 24 hours.
Exclusion criteria
Exclusion criteria: Patient is pregnant or lactating;Proven or suspected acute primary brain lesion such as traumatic brain injury, cerebrovascular accident, or hypoxic-ischemic encephalopathy; spinal cord injury or myasthenia gravis; Mean arterial blood pressure (MAP) that is less than 50 mmHg despite adequate resuscitation and vasopressor therapy; Heart rate less than 55 beats per minute without being treated with a beta-blocker or a high grade atrio-ventricular block in the absence of a functioning pacemaker; subjects with portal hypertension complicated by gastrointestinal bleeding, acute liver failure or Hepatic encephalopathy; A history of schizophrenia, epilepsy or Parkinsonian syndrome; patients who can not finish the evaluation of pain, sedation or delirium due to severe dementia, coma or end-stage disease, etc.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| amplitude-integrated electroencephalogram (aEEG);spectral entropy;relative spectral power;spectral edge frequency; | — |
Secondary
| Measure | Time frame |
|---|---|
| RASS score;mechanical ventilating duration;length of ICU stay;proportion of patients with delirium;heart rate;blood pressure;cumulative dose of rescue sedative agent;NSE;s100ß;CPOT score; | — |
Countries
China
Contacts
Public ContactChen Minying
the First Affiliated Hospital of Sun Yat-sen University
Outcome results
None listed