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Effects of different remifentanil target concentrations on MAC BAR of sevoflurane in neurosurgical patients with skull pin fixation

Effects of different remifentanil target concentrations on MAC BAR of sevoflurane in neurosurgical patients with skull pin fixation

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR-IOR-16008736
Enrollment
Unknown
Registered
2016-06-28
Start date
2016-07-10
Completion date
Unknown
Last updated
2017-04-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

neurosurgery

Interventions

R0 group:inhaled sevoflurane
R1 group:inhaled sevoflurane and i.v. target-controlled infusion of remifentanil 1 ng/ml
R2 group:inhaled sevoflurane and i.v. target-controlled infusion of remifentanil 2 ng/ml

Sponsors

Southern District of Anhui Provincial Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
20 Years to 60 Years

Inclusion criteria

Inclusion criteria: 1. Neurosurgical patients with skull pin fixation; 2. Aged 20-60 yrs; 3. BMI<30kg/m2; 4. ASA physical status I-II.

Exclusion criteria

Exclusion criteria: 1. History of cardiac, pulmonary, liver or renal disease; 2. Drug or alcohol abuse; 3. Current use of any vasoactive medications; 4. Recent use of any medications known to affect MAC or sympathetic adrenergic response; 5. Contraindication for inhalation induction.

Design outcomes

Primary

MeasureTime frame
MAC BAR of sevoflurane in neurosurgical patients with skull pin fixation;Plasma remifentanil concentration;—

Secondary

MeasureTime frame
Plasma epinephrine concentration;Plasma norepinephrine concetration;Heart rate;Mean arterial pressure;Bispectral Index;—

Countries

China

Contacts

Public ContactKang Fang

Southern District of Anhui Provincial Hospital

kangfang199771@outlook.com+86 18155127799

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026