Helicobacter pylori infection
Conditions
Interventions
Group A:Bioflor+Rabeprazole+Amoxicillin+Clarithromycin (d1~d10), Bioflor (d11~d14)
Group B:Rabeprazole+Bismuth potassium citrate+Amoxicillin+Clarithromycin (d1~d10)
Group C:Rabeprazole+Amoxicillin+Clarithromycin (d1~d10)
Sponsors
Peking University First Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: (1) Hp positive NUD patients in line with HP eradication indications; (2) All selected candidates must obtain a diagnosis by endoscopy (within 1 month); (3) the rapid urease test was positive, or urea breath test was positive within 2 weeks before endoscopy or within 1 month after endoscopy; (4) Aged 18 to 65 years old, male or female; (5) Havnt received formal HP eradication therapy; (6) Havnt taking any probiotic recently; (7) Signed the informed consent.
Exclusion criteria
Exclusion criteria: (1) Have taken antibiotics or bismuth agent within 4 weeks before treatment, or have taken H2RA or PPI within 2 weeks before treatment; (2) Pregnancy or breast-feeding women; (3) Patients have any other serious illness that would affect the study, such as severe liver disease, heart disease, cerebrovascular disease, kidney disease, cancer or alcoholism disorders; (4) Allergy to drugs using in this study; (5) Have participated in other drug study within 3 months before this trial; (6) Patients who is unable to express their main complaint properly, such as psychosis, severe neurosis or who cannot cooperate in this trial; (7) Patients with severe immune deficiencies or easily lead to fungal infections.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hp eradication rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| epigastric distention;belching;epigastric pain;poor appetite;diarrhea; | — |
Countries
China
Contacts
Public ContactFulian Hu
Peking University First Hospital
Outcome results
None listed