non-alcoholic fatty liver disease
Conditions
Interventions
Intervention group:1600IU/d Vitamin D supplementation
control group:Placebo
Sponsors
Southern Medical University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Subjects included in this trial should be aged 40-70 years; diagnosed as NAFLD through B mode ultrasound of liver and with elevated ALT during the last 6 months; lived in Guangdong province for at least 5 years
Exclusion criteria
Exclusion criteria: Patients were excluded if they met any of the following exclusion criteria: alcohol intake >140 grams/week for male and 70 g/week for female; uncontrolled diabetes; evidence of other forms of liver disease, including hepatitis B (positive serum hepatitis B surface antigen), hepatitis C (positive hepatitis C viral RNA), autoimmune hepatitis (positive autoimmune serology and consistent biopsy), drug-induced liver disease based on exposure and history; history of gastrointestinal bypass or use of drugs known to cause hepatic steatosis; evidence of hepatocellular carcinoma; renal insufficiency; mental or physical disability; used of vitamin D supplements in the past 3 months; do outdoor work in long term period
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| ALT;AST;?-GT; | — |
Secondary
| Measure | Time frame |
|---|---|
| B Ultrasound liver;fasting insulin level;HOMA-IR;glucose and lipids profiles; | — |
Countries
China
Contacts
Public ContactZheqing Zhang
Southern Medical University
Outcome results
None listed