cardiac disease
Conditions
Interventions
dexmedetomidine group(D):dexmedetomidine
Non-dexmedetomidine(ND):Non-dexmedetomidine
Sponsors
Department of Anesthesiology, Guizhou Provincal People’s Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: Patients were eligible for enrolment if they were more than 18 years of age, undergoing primary elective valve surgery with cardiopulmonary bypass, and not undergoing additional procedures such as coronary artery bypass surgery and were able to speak sufficient Chinese to complete the neurocognitive tests.
Exclusion criteria
Exclusion criteria: Exclusion criteria included below 18years of age or more than 60 years of age dialysis dependent renal failure, liver transaminases more than 1.5 times normal, pre-existing diagnosis of schizophrenia, dementia,recent stroke, known disorder affecting cognition, severe anxiety states, recent alcohol abuse or a history of chronic opioid or other psychotropic drug use.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| MMSE score;MoCA score; | — |
Secondary
| Measure | Time frame |
|---|---|
| glutamic acid;glycine;?- aminobutyric acid;cerebral oxygen metabolism; | — |
Countries
China
Contacts
Public ContactFang Kaiyun
Department of Anesthesiology, People’s Hospital of Guizhou Province
Outcome results
None listed