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Efficacy of a single preoperative Dexamethasone dose to prevent postoperative recurrent larygeal nerve palsy, parathyroid dysfunction, and laryngopharyngeal symptoms: a double blind randomized controlled trial

Efficacy of a single preoperative Dexamethasone dose to prevent postoperative recurrent larygeal nerve palsy, parathyroid dysfunction, and laryngopharyngeal symptoms: a double blind randomized controlled trial

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR-IOR-16008579
Enrollment
Unknown
Registered
2016-06-01
Start date
2016-06-01
Completion date
Unknown
Last updated
2017-04-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

thyroid cancer

Interventions

Sponsors

Thyroid and Parathyroid Surgery Center, West China Hospital of Sichuan University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: (1) Patients with age more than 18 years old; (2) patients were diagnosis with thyroid disease needed surgery: lobe thyroidectomy or total thyroidectomy; (3) Patients voluntary to participate in this study;

Exclusion criteria

Exclusion criteria: (1) Patients with age younger than 18 years old; (2) Patients with preoperarive anti-vomit or anti-cough drugs usage; (3) Patients with history of depression or chronic pain or I/II diabete or with severe vomit; (4) Pregnant woman; (5) Patients with surgical history of neck or thyroid; (6) Patients with history of allergy for dexamethasone; (7) Patients needed operation on sternum; (8) Patients with history of I131 radiation; (9) Patients with long term useage of steroid or immune suppression; (10) Patients with preoperative voice change or confirmed vocal paralysis; (11) Patients needed dissection of lateral neck lymph node; (12) Patients with other cancers; (13) Patients with no willing to participate in this study; (14) Patients with hypothyroidism.

Design outcomes

Primary

MeasureTime frame
Nausea or vomit;cough;Pain;Function of recurrent laryngeal nerve;Function of Parathyroid;Complications related to Dexamethasone;

Secondary

MeasureTime frame
The useage of the drug for vomit;Postoerpative bleeding;The useage of the drug for pain;Postoperative hospital stay days;Postoperative complications according to the Clavien system;

Countries

China

Contacts

Public ContactJingqiang Zhu

Thyroid and Parathyroid Surgery Center, West China Hospital of Sichuan University

zjq-wkys@163.com+86 028-85422467

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026