Pakinson's Dissease
Conditions
Interventions
Intervention Group:Sifrol/XI Ning+compound Cong Rongjing
Control Group:Sifrol/XI Ning+placebo
Sponsors
Fujian University of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
50 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Patients meeting the diagnostic criteria of PD; 2. meeting the TCM pattern criteria of deficiency of marrow-reservoir; 3. meeting the classification criteria of PD (Early-stage PD patients; The stage of Hoehn&Yahr Scale is between 1-2.5 levels.); 4. aged between 50 and 70; 5. receive the treatments voluntarily and sign informed consent form.
Exclusion criteria
Exclusion criteria: 1. Patients with Parkinsons syndrome and Parkinsonism-plus syndrome or other non-PD patients; 2. MRI scanning contraindication; 3. With abnormal signal shadow of conventional MRI scan(does not rule out the lacunar infarction); 4. With history of limb trauma, neuromuscular junction and muscle disease; With head injury, long-term exposure to chemicals and other diseases; 5. serious heart,liver or kidney diseases,diabetes,mental and neurological disorders, severe infection, tumour, encephalitis, and so on. Allergic to the treatment drug. 6. aking the western medication of PD, but the the time interval from last time taking medication to the visit is less than 7 days; Taking traditional Chinese medication of PD, but the the time interval from last time ttaking medication to the visit is less than 3 months; 7. patients have already participated in other clinical intervention research program in the past 3 months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Unified Parkinson's Disease Rating Scale; | — |
Secondary
| Measure | Time frame |
|---|---|
| Hoehn-Yahr Rating Scale;Parkinson Disease Question-39;TCM(traditional chinese medicine) symptoms rating scale;change of medication’s dosage;The content of alpha -Synuclein and phosphorylated alpha -Synuclein in the patients' plasma; | — |
Countries
China
Contacts
Public ContactCai Jing
Fujian University of Traditional Chinese Medicine
Outcome results
None listed