FindTrial
Sign In

Protective effect of tight glucose control during cardiopulmonary bypass on gastrointestinal function in adult non-diabetic patients undergoing aortic valve replacement

Protective effect of tight glucose control during cardiopulmonary bypass on gastrointestinal function in adult non-diabetic patients undergoing aortic valve replacement

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR-IOR-16008229
Enrollment
Unknown
Registered
2016-04-06
Start date
2016-04-01
Completion date
Unknown
Last updated
2017-04-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Heart valve disease

Interventions

An insulin group:Patients received a continuous intravenous insulin infusion from the induction of anesthesia to discontinuation of CPB. The dosage of insulin was regulated according to blood glucose
A control group:Patients in the control group received a measurement of blood glucose every 20 minutes during surgery, and did not receive insulin during surgery unless their blood glucose levels exce

Sponsors

Dept. of Cardiovascular Surgery of Zhongshan Hospital of Fudan University
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: Isolated aortic valve replacement, New York Heart Association (NYHA) class I-III, left ventricular ejection fraction (LVEF)>35%, normal liver and kidney function without history of liver or kidney disease, no inflammatory or immunological diseases and age>18 years.

Exclusion criteria

Exclusion criteria: Any concomitant diseases including coronary heart disease, cardiomyopathy, diabetes mellitus, thyroid disease, infective endocarditis, malignant tumor, and hematological disorders; second cardiac operation; unstable preoperative hemodynamics; impairment of blood glucose control; and postoperative requirement of intra-aortic balloon pump or left ventricular assist device.

Design outcomes

Primary

MeasureTime frame
Blood glucose level;Plasma insulin level;pH value of gastric juice, gastric intramucosal pH , serum gastrin concentration, erythrocyte counts in gastric juice;Inflammatory, cytokines IL-6;BUN, Scr, Cys c;—

Countries

China

Contacts

Public ContactWenJun Ding

Dept. of Cardiovascular Surgery of Zhongshan Hospital of Fudan University, Shanghai

dwj12191@163.com+86 13564980808

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026