Neuro-navigated repetitive Transcranial Magnetic Stimulation (rTMS) for depression in dementia

Conditions

Major Neurocognitive Disorders

Hanna Lu, Sandra Sau Man Chan, Suk Ling, Arthur Dun-Ping Mak, Lin Shi et al. (7 authors)

Translational Psychiatry2026-09-02

Predictive values of pre-treatment brain age models to rTMS effects in neurocognitive disorder with depression: Secondary analysis of a randomised sham-controlled clinical trial

Hanna Lu, Jing Li, Sandra Sau Man Chan, Suk Ling, Vincent Mok et al. (8 authors)

Dialogues in Clinical Neuroscience2024-07-046 citations

10.1080/19585969.2024.2373075

Clinical and radiomic features for predicting the treatment response of repetitive transcranial magnetic stimulation in major neurocognitive disorder: Results from a randomized controlled trial.

Lu H, Chan SSM, Ma S, Lin C, Mok VCT, Shi L, Wang D, Mak AD, Lam LCW.

2022-08-0114 citations

10.1002/hbm.26032

Interventions

Two groups:Repetitive Transcranial Magnetic Stimulation (rTMS), 10 Hz, 30 trains and 1500 pulses per day, 3 weeks, 5 (once daily) treatment sessions per week, versus Sham Transcranial Magnetic Stimula

Eligibility

Sex/Gender

All

Age

60 Years to 90 Years

Inclusion criteria

Inclusion criteria: Major Neurocognitive Disorder due to AD; Major Vascular Neurocognitive Disorder with small vessel disease; Cornell Scale for Depression in dementia (CSDD) with a rating of 7 or over.

Exclusion criteria

Exclusion criteria: Past history of bipolar affective disorder or psychosis; Physically frail affecting attendance to TMS sessions; Already attending other brain stimulation therapies; History of major neurological deficit including history of major stroke, transient ischemic attack or traumatic brain injury; Significant communicative impairment.

Design outcomes

Primary

Measure	Time frame
Depressive symptoms;	—

Secondary

Measure	Time frame
Global cognitive function;Neuropsychiatric symptoms;Quality of life;Serum BDNF levels;	—

Countries

China

Contacts

Public ContactLinda Chiu Wa LAM

Department of Psychiatry, The Chinese University of Hong Kong

cwlam@cuhk.edu.hk+852 26076027

Outcome results

None listed