Functional abdominal pain syndrome
Conditions
Interventions
experimental group:intracolonic lidocaine spraying
control group:intracolonic saline spraying
Sponsors
Department of Gastroenterology, West China Hospital, Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Aged between 18-70 years; 2. no warning symptoms:stool with blood or bloody stool, melena or fecal occult blood test positive, abdominal mass, unexplained weight loss(more than 4.5Kg), iron-deficiency anemia, family history of colorectal cancer, family history of inflammatory bowel disease; 3. meet the Rome III standard for adults with functional abdominal pain syndrome; 4. medical history, physical examination and other examinations found no pathological changes that can explain chronic abdominal pain; 5. willing to participate in the study and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Pregnant women and lactating women; 2. Have a history of gastrointestinal or abdominal surgery; 3. painless colonoscopy found pathological changes that can cause abdominal pain: inflammatory bowel disease,intsetinal tumor, stricture of colon, fistula, hemorrhoid,anal fissure, perianal abscess; 4. contraindication of lidocaine: lidocaine allergy,liver and kidney dysfunction,congestive heart-failure, hypotension,cardiac conduction block, Wolff-Parkinson-White syndrome,pulmonary insufficiency; 5. taking drugs that can effect the metabolism of lidocaine,and can not or is not willing to drug withdrawal: Cimetidine, beta-blocker(propranolol, metoprolol), barbiturate(thiopental sodium, phenobarbitone), sodium nitroprusside, mannitol, silvadene, amphotericin B, ampicillin.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Degree of abdominal pain; | — |
Secondary
| Measure | Time frame |
|---|---|
| heart rate;bloodpressure;arterial partial pressure of oxygen; | — |
Countries
China
Contacts
Public ContactHu Bing
Department of Gastroenterology, West China Hospital, Sichuan University
Outcome results
None listed