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The effect of celecoxib on early postoperative cognitive dysfunction in elderly patients undergoing Lower limb arthroplasty

The effect of celecoxib on early postoperative cognitive dysfunction in elderly patients undergoing lower limb arthroplasty: a randomised double-blind, placebo-controlled trial

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR-IOR-16008168
Enrollment
Unknown
Registered
2016-03-27
Start date
2016-04-01
Completion date
Unknown
Last updated
2017-10-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

postoperative cognitive dysfunction

Interventions

Control group:starch
Celecoxib group:Celecoxib group

Sponsors

Xuzhou Tumor Hospital
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: ASA I or II; 65 to 75 years of age; scheduled for knee or hip arthroplasty.

Exclusion criteria

Exclusion criteria: Mini-Mental State Examination (MMSE) score35; patients on analgesics or antidepressants; history of peptic ulcer; inability to comply with the study protocol or procedures

Design outcomes

Primary

MeasureTime frame
Postoperative cognitive function;—

Secondary

MeasureTime frame
visual analogue pain scale (VAS) scores;plasma levels of pro-inflammatory cytokines;—

Countries

China

Contacts

Public ContactYangzi Zhu

Xuzhou Tumor Hospital

zyz0782111034@sina.com+86 15862149539

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 23, 2026