hypertension
Conditions
Interventions
treatment group:intranasal dexmedetomidine 1ug/kg
control group:intranasal 0.9%NS 0.01ml/kg
Sponsors
The First Affiliated Hospital, Sun Yat-Sen University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Aged 65 to 75 years old; 2. BMI < 30 kg/m2; 3. ASA II to III level; 4. Grade of Hypertension I to II level.
Exclusion criteria
Exclusion criteria: 1. Refused to participate in the study; 2. Allergic to anaesthetic; 3. Secondary hypertension (such as: pheochromocytoma, renal vascular stenosis, etc.); 4. History of stroke (cerebral infarction, cerebral hemorrhage history); 5. The new diagnosis or untreatment of high blood pressure; 6. Abnormal liver function (Child class B or above); 7. Renal decompensation (SCR > 177 umol/L); 8. Taking clonidine or other alpha 2 agonists; 9. Heart failure, myocardial infarction; 10. Preoperative heart rate is less than 45 BPM, II or III degree atrioventricular block; 11. Asthma patients, patients with sleep apnea syndrome; 12. People with mental illness, patients with long-term use of sedative and analgesic drug.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| mean arterial pressure; | — |
Secondary
| Measure | Time frame |
|---|---|
| Heart rate;SpO2;OAA/S sedation scale; | — |
Countries
China
Contacts
Public ContactMo Liqiu
The First Affiliated Hospital, Sun Yat-Sen University
Outcome results
None listed