Infertility, diminished ovarian reserve
Conditions
Interventions
Group A:pronuclear embryo transfer(D1 transfer), reduce culture time in vitro, pronuclear embryo transfer
Group B:cleavage embryo transfer(D3 transfer)
Sponsors
Maternal and Child Health Hospital of Guangxi Zhuang Autonomous Region
Eligibility
Sex/Gender
Female
Age
36 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Infertility time>=12 months, women who have at least one of the following indications for IVF: (1) Ovulation dysfunction and failed to become pregnant from ovulation induction treatment; (2) Tubal and pelvic cavity factors; (3) Endometriosis; (4) Male factors; 2. Women who must meet at least two of following indications: (1) Female aged >= 36 years; (2) Antral follicle count of bilateral ovaries 10IU/L.
Exclusion criteria
Exclusion criteria: 1. Women height<=145cm; 2. Women or their partner with abnormal chromosome karyotype excluding chromosome polymorphism; 3. Intracytoplasmic sperm injection (ICSI); 4. Normal fertilized embryos<1; 5. Women is unsuited to transfer fresh embryos due to various reasons; 6. Women who has developed moderate to severe OHSS(Golan standard); 7. Women who abnormal uterine diseases, such as uterine malformation(single angle of uterus, mediastinum uterus, double angle of uterus, double uterus), uterine adenomyosis, submucosal uterine fibroids, intrauterine adhesions and so on; 8. Hydrosalpinx is not treated; 9. Women with medical condition that represent contraindication to assisted reproductive technology and/or pregnancy, such as poorly controlled Type I or Type II diabetes; undiagnosed liver disease or dysfunction (based on serum liver enzyme testing); renal disease or abnormal serum renal function; significant anemia; history of deep venous thrombosis, pulmonary embolus, or cerebrovascular accident; uncontrolled hypertension, known symptomatic heart disease; history of or suspected cervical carcinoma, endometrial carcinoma, or breast carcinoma; undiagnosed vaginal bleeding.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| implantation rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| live birth rate; | — |
Countries
China
Contacts
Public ContactBo Zhang
Maternal and Child Health Hospital of Guangxi Zhuang Autonomous Region
Outcome results
None listed