Acute post-operative pain
Conditions
Interventions
Two groups:5% lignocaine medicated plaster (lignopad) 1 patch (700mg) over 24 hours, three days, once a day, versus Placebo 1 patch over 24 hours, three days, once a day
Sponsors
Prince of Wales Hospital, Hospital Authority
Eligibility
Sex/Gender
Female
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. Patient 18-60 years old; 2. Planned major abdominal non-malignant gynaecological surgery 3. Planned open midline surgical incision 4. Willing and able to give consent 5. ASA (American Society of Anaesthesiologists) Class 1 to 2.;Inclusion criteria: 1. Patient 18-60 years old; 2. Planned major abdominal non-malignant gynaecological surgery 3. Planned open midline surgical incision 4. Willing and able to give consent 5. ASA (American Society of Anaesthesiologists) Class 1 to 2.
Exclusion criteria
Exclusion criteria: 1. Patient refused either intravenous PCA or lignopad?; 2. Contraindicated to lignopad?: hypersensitivity to local anaesthetics of the amide type; inflamed or injured skin peri-surgical site (e.g. atopic dermatitis, open wounds); 3. Planned transverse or oblique incisional approach; 4. Allergy or tolerance to opiates; 5. Extensive existing midline abdominal scarring; 6. Unable to communicate in English or Chinese.;Exclusion criteria: 1. Patient refused either intravenous PCA or lignopad?; 2. Contraindicated to lignopad?: hypersensitivity to local anaesthetics of the amide type; inflamed or injured skin peri-surgical site (e.g. atopic dermatitis, open wounds); 3. Planned transverse or oblique incisional approach; 4. Allergy or tolerance to opiates; 5. Extensive existing midline abdominal scarring; 6. Unable to communicate in English or Chinese.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Difference in mean visual analogue scale (VAS) pain score at rest and on movement at 24 hours after extubation;;Difference in mean visual analogue scale (VAS) pain score at rest and on movement at 24 hours after extubation; | — |
Secondary
| Measure | Time frame |
|---|---|
| Mean visual analogue scale (VAS) pain scores at rest and on movement at 48 and 72 hours after extubation;Intravenous PCA morphine consumption at 24, 48 and 72 hours after extubation;Pre-operative and post-operative peak flow rate difference comparison at 24, 48 and 72 hours extubation;Complications arising from lignopad? application;;Mean visual analogue scale (VAS) pain scores at rest and on movement at 48 and 72 hours after extubation;Intravenous PCA morphine consumption at 24, 48 and 72 hours after extubation;Pre-operative and post-operative peak flow rate difference comparison at 24, 48 and 72 hours extubation;Complications arising from lignopad? application; | — |
Countries
China
Contacts
Public ContactLydia Lau;Lydia Lau ;
Prince of Wales Hospital, Hospital Authority;Prince of Wales Hospital, Hospital Authority
Outcome results
None listed