Kawasaki disease
Conditions
Interventions
IVIG+ASP group:IVIG(2g/kg.d)+ASP(30-50mg/kg.d)
IVIG+ASP+methylprednisolone group:IVIG+ASP+methylprednisolone
Sponsors
Children’s Hospital affiliated to Capital Institute of Pediatrics
Eligibility
Sex/Gender
All
Age
No minimum to 18 Years
Inclusion criteria
Inclusion criteria: The KD diagnosis was based on 5th edition diagnostic criteria revised by the Japanese KD Research Committee: (1) fever lasting longer than 5 d (including cases who were responsive to treatment with a fever lasting less than 5 d); (2) binocular conjunctival congestion (no exudation); (3) changes in the lip and oral cavity, flushed lips and rhagades, strawberry-like tongue, oral and pharyngeal mucosal diffuse hyperemia; (4) polymorphous rash; (5) changes in the tail end of limbs, palmoplantar redness, hard swelling in the finger (toe) tip; (6) acute non-suppurative cervical lymphadenopathy that was often unilateral, diameter greater than 1.5 cm. KD was diagnosed if patients presented with five or more of the criteria. KD was also diagnosed in patients who met four of the criteria and had a coronary artery aneurysms or coronary artery ectasia observable by two-dimensional echocardiogram or coronary arteriography. Non-responders were defined as: (1) continued high fever (>38.0 degree C) 36 h after treating with IVIG+ASP in 5-10 d; or (2) recurrent fever within 2-7 d after IVIG infusion, accompanied by other clinical manifestations of KD.
Exclusion criteria
Exclusion criteria: (1) Relapsing KD; (2) Rehospitalization due to resistant to the initial treatment; (3) Before admission received non-standard therapy; (4) Concurrent with other vascular inflammatory diseases; (5) Incomplete clinical data; (6) Do not meet the IVIG no response definition.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| white blood cell;hemoglobin;platelet;the percent of neutrophile granulocyte;alanine transaminase;aspartate aminotransferase;gamma-glutamyl transpeptidase;sodium;erythrocyte sedimentation rate;C-reactive protein;albumin;Gene; | — |
Countries
China
Contacts
Public ContactXiaohui Li
Outcome results
None listed