Patients undergoing laparoscopic cholecystectomy surgery
Conditions
Interventions
neostigmine group:intravenous injection of neostigmine and atropine
placebo group:intravenous injection of normal saline
Sponsors
The second affiliated hospital of Zhejiang University
Eligibility
Sex/Gender
All
Age
18 Years to 100 Years
Inclusion criteria
Inclusion criteria: Patients scheduled for laparoscopic cholecystectomy surgery under general anesthesia; intraoperative use muscle relaxants; aged more than 18 years old, with American Society of Anesthesiologists grading I-III.
Exclusion criteria
Exclusion criteria: Cardiopulmonary dysfunction, acute anterior surgery pulmonary disease, chest or abdominal surgery, multiple trauma, abnormal liver function, renal insufficiency or renal failure, the potential of neuromuscular disease, preoperative use of drugs interfere with neuromuscular transmission, contraindication for neostigmine and atropine, surgical position hinder judgment by the ulnar nerve monitoring the degree of muscle relaxation, intraoperative hypothermia (T 35kg/m2).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| incidence of postoperative nausea and vomiting;incidence of arrhythmia;incidence of oxygen desaturation after extubation; | — |
Secondary
| Measure | Time frame |
|---|---|
| the incidence of RNMB;length of PACU stay time.;Pulmonary complications within 7 postoperative days; | — |
Countries
China
Contacts
Public ContactMin Yan
Outcome results
None listed