menopause related disease
Conditions
Interventions
control group:placebo
Sponsors
Guangdong Provincal hospital of Chinese Medicine
Eligibility
Sex/Gender
Female
Age
41 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. Women aged 41-60 years; 2. Meet the diagnosis of dyslipidemia;and is primary hyperlipidemia; 3. The level of blood lipid should be TC 5.18mmol/L to 6.19mmol/L; LDL-C 3.37 mnol/L to 4.12mmol/L; TG1.70mnol/L to 2.25mmol/L; 4. 10 year cardiovascular risk<10% (with QRISK2Risk assessment calculator); 5. Meet the diagnosis criteria of TCM syndrome of Liver and kidney Yin deficiency syndrom; 6. Kupperman index (KI)<15; 7. Did not use any of the following treatment for at least 4 weeks before entry into the study: Other Drugs Effect of blood lipid reduction, hormone therapy, selective elective estrogen receptor modulators, aromatase inhibitors, soybean extracts or Chinese medicine; 8. Be able and voluntary to sign informed consent.
Exclusion criteria
Exclusion criteria: 1. Patients with secondary dyslipidemia and with familial hypercholesterolemia 2. High risk factor of coronary heart disease, such as unstable angina, acute myocardial infarction, postoperative of coronary stent implantation or postoperative of coronary artery bypass grafting; 3. the risk of 10 year cardiovasular heart disease >=10%(with QRISK2 risk assessment calculator); 4. Over 10 years of I types of diabetes,and with kidney disease or other cardiovascular disease risk factors; 5. Patients with carotid artery stenosis, transient ischemic attack, stroke and peripheral vascular disease patients; 6. Severe liver or/and renal insufficiency;hematopoietic system disease or malignant tumor; 7. Patients with mental illness (schizophrenia, bipolar disorder, paranoid psychosis or paitents obvious suicidal depression); 8. Alcohol consumption; 9. Participate in the I, II period clinical trial within the last 6 months or III, IV period clinical trial within the last 3 months; 10. Allergic to trial medication or f patients with allergic constitution; 11. Patients with muscle or joint diseases which hinder the paitents do moderate intensity exercis(such as osteoarthritis, rheumatoid arthritis, synovitis and so on).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| blood lipids;adiponectin;leptin;Insulin, blood glucose, C reactive protein, vascular endothelial growth factor;Carotid artery ultrasonography; | — |
Secondary
| Measure | Time frame |
|---|---|
| Greene climactic scale; | — |
Countries
Chine
Contacts
Public ContactXiaoyun Wang
Outcome results
None listed