sarcopenic obesity
Conditions
Interventions
Nutrition Plus Exercise Group:nutrition intervention+exercise intervention
Exercise Group:exercise intervention
Control Group:no intervention
Sponsors
Zhejiang Hospital
Eligibility
Sex/Gender
All
Age
65 Years to 100 Years
Inclusion criteria
Inclusion criteria: 1. aged 65 years or more; 2. according with the consensus for sarcopenia diagnosis by Asia working Group for Sarcopenia (AWGS): low muscle mass plus low muscle strength and/or low physical performance; 3. in accordance with obesity defined by Baumgartner et al percentage of body fat greater than the 60th percentile of the study reference group. The cutoff values of obesity are 26.3% in men and 33.2% in women in reference to the previous results; 4. volunteer to sign informed consent; 5. with stable chronic disease state.
Exclusion criteria
Exclusion criteria: 1. taking nutritional supplements regularly or taking part in other forms of clinical trials within the past 3 months; 2. suffering from acute infection or acute cerebral organic diseases in recent 6 months; 3. equipped with a pacemaker; 4. suffering from serious heart disease, severe hemodynamic instability, severe bradycardia and tachycardia at rest; 5. suffering from renal failure (creatinine clearance rate<=60ml/min/1.73m2); 6. severe cognitive impairment (mini-mental state examination, MMSE<=17) or extremity disability, unable to complete gait speed and grip strength measurement; 7. have difficulty in swallowing or oral intake; 8. recently received a major surgery or extremity surgery, unsuitable to accept exercise intervention; 9. unsuitable to take part in the study judged by clinicians due to medical consideration.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| short physical performance battery;grip strength;6-meter usual gait speed;free fat mass;appendicular skeletal muscle mass;percentage of body fat; | — |
Secondary
| Measure | Time frame |
|---|---|
| body fat;upper arm circumference;calf circumference;waist-to-hip ratio,;Activities of Daily Living;Instrumental Activity Daily Living;hemoglobin;albumin;transferrin;fasting blood glucose;total cholesterol;triglyceride;high density lipoprotein cholesterol;low density lipoprotein cholesterol;serum 25-hydroxyvitamin D;hypersensitive C-reactive protein; | — |
Countries
China
Contacts
Public ContactShanshan Shen
Outcome results
None listed