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The effect of controlled hypotension with combination different anesthetic drug on cerebral ischemia and reperfusion in craniocerebral surgery

The effect of controlled hypotension with combination different anesthetic drug on cerebral ischemia and reperfusion in craniocerebral surgery

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR-IOR-15007407
Enrollment
Unknown
Registered
2015-11-04
Start date
2016-01-01
Completion date
Unknown
Last updated
2017-04-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

cerebral ischemia and reperfusion

Interventions

A:remifentanil+sevoflurane
B:remifentanil+propofol
C:sevoflurane+propofol
D:nitroglycerin

Sponsors

Department of anesthesiology, People's hospital of Xinjiang Uyghur Autonomous Region, Urumchi
Lead Sponsor

Eligibility

Sex/Gender
All
Age
45 Years to 65 Years

Inclusion criteria

Inclusion criteria: Craniocerebral surgery with general anesthesia and controlled hypotension patients, no matter sex, ASA I-II, aged 45 to 65 years old.

Exclusion criteria

Exclusion criteria: 1. heart or cerebrovascular accident history; 2. severe hypertension; malignant arrhythmia; 3. important viscera function is not complete; 4. the coagulation function abnormality or long-term taking anticoagulant drugs; 5. taking sedatives, drug of disturb the adrenal function or the sympathetic nervous.

Design outcomes

Primary

MeasureTime frame
SOD;MDA;EAA;—

Countries

China

Contacts

Public ContactXu Guiping
xgpsyl@126.com+86 13669988366

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026