elective laparoscopic colorectal surgery performed under general anesthesia
Conditions
Interventions
DEX group:A loading dose of DEX 1.0ug/kg will be injected intravenously over 10 mins after induction of aneshtesia and intubation, followed by continous infusion of 0.5-1.0ug/kg/h until the end of sur
Control group:the equal volume of normal saline will be given
Sponsors
Shaoxing People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. Patients aged 18-60 years of age, male and female; 2. Body image index is 18-25; 3. Patients, ASA I-II scheduled for elective laparoscopic colorectal surgery performed under general anesthesia; 4. Patients familiar with all the procedure and evaluation, agreed to participate in this experiment, and sign the informed consent.
Exclusion criteria
Exclusion criteria: 1. Obese patient with body image index more than 25; 2. Patients with ASA class more than grade II, severe cardiac, lung, hepatic and renal diseases; 3. Systemic infectious disease (body temperature more than 38 degree C); 4. Patients with leukemia (WBC more than 10000/uL) 5. Patients with HR less than 55 beat per minute; 6. Patinets with diabetes mellitus or potential difficult airway.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| blood bacterial culture;bacterial DNA measurement;bacterial endotoxin measuremnt;IFN-garma;IL-4;CD3;CD4;CD(16+56);CD19;CD45; | — |
Secondary
| Measure | Time frame |
|---|---|
| 30-days post-operative complication and motality rate in hospital;intestinal microbial population;D-lactic acid;intestinal fatty acid binding protein; | — |
Countries
China
Contacts
Public ContactLi Yuhong
Outcome results
None listed