familial adenomatous polyposis
Conditions
Interventions
Sponsors
The Military General Hospital of Beijing PLA
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: The trial population was patients with FAP, defined as the presence of 100 adenomas in the large intestine, or a germline mutation in the adenomatous polyposis coli (APC) gene. All the subjects participating in the trial were aged >18 and <60 years,and did not accepted colectomy. FAP patients had received colonoscopy regularly and already had polyps 10mm or larger removed endoscopically, and did Not taken antibiotics, calcium, corticosteroids and other non steroidal anti-inflammatory drugs in the first 3 months of the group.
Exclusion criteria
Exclusion criteria: The following were excluded from the trial: (1) patients with active cancer at the time of entry; (2) those with Severe constipation; (3) individuals with a history of stroke or gastric/duodenal ulcers; (4) those with bleeding tendency; (5) those with abnormal prothrombin time; (6) people with known allergy to berberine hydrochloride; (7) those who were pregnant or planned to become pregnant during the trial period, and (8) those taking an NSAID, COX-2 inhibitors or calcium.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The number and size of the total number of high-risk adenomas in the whole colon;The number and size of 5cm in the rectum from the dentate line;The changes of microbial population, diversity and distribution of intestinal microflora in the feces;The changes of microbial population, diversity and distribution of intestinal microflora in the colon tissue; | — |
Countries
China
Contacts
Public ContactLi Na
Outcome results
None listed