Infertility
Conditions
Interventions
Sponsors
Eligibility
Inclusion criteria
Inclusion criteria: 1. Compliance with IVF-ET inclusion criteria; 2. the patient had undergone IVF-ET more than once but do not successful embryo implantation; 3. Vaginal B super ovulation confirmed ovulation occurs; 4. Aged <= 40 years old; 5. According to the foundation of the state of ovarian, patients accept controlled ovarian hyperstimulation programs; 6. Signed informed consent, voluntary acceptance of two courses of treatment examination; 7. Not taking any hormones other drugs were within the first month of treatment.
Exclusion criteria
Exclusion criteria: 1. Contraindicated in patients with IVF-ET; 2. Failing to treat, can not determine the efficacy of other factors; 3. Who is participating in other clinical trials; 4. Serious primary disease with cerebral vascular, cardiovascular, liver, kidney hematopoietic tem; mental illness; blood glucose control in diabetic patients.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Biochemical pregnancy rate;Clinical pregnancy rate;Live birth rate;Vaginal B ultrasound;Gene expression profile of endometrial tissue;mRNA and protein expression of target gene;Estrogen receptor;Progesterone receptor;Vascular endothelial growth factor;IL-11;Leukemia inhibitory factor;C-reaction protein;miRNA; | — |
Secondary
| Measure | Time frame |
|---|---|
| Serum sex hormone levels;Biological and safety indicators; | — |