septic shock
Conditions
Interventions
experimental :esmolol
control :isotonic line
Sponsors
the First Affiliated Hospital of Zhengzhou University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria are the presence of septic shock requiring norepinephrine to maintain a mean arterial pressure (MAP) of 65mm Hg or higher despite appropriate volume resuscitation (PAOP>=12mmHg CVP>=8mmHg), a heart rate of 95/min or higher.
Exclusion criteria
Exclusion criteria: 1. Younger than 18 years; 2. beta-blocker therapy prior to randomization; 3. Presence of pronounced cardiac dysfunction; 4. significant valvular heart disease; 5. pregnancy suckling; 6. Presence of severe basic diseases, such as AIDS, terminal maligant cancer, which probably be the main cause of death.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| twenty-eight day mortality; | — |
Secondary
| Measure | Time frame |
|---|---|
| heart rate;90-day mortality;norepinephrine requirements; | — |
Countries
China
Contacts
Public ContactTongwen Sun
Outcome results
None listed