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The molecular mechanism and incidence of POCD in elderly patients of non cardiac operation under sevoflurane inhalation anesthesia

The molecular mechanism and incidence of POCD in elderly patients of non cardiac operation under sevoflurane inhalation anesthesia

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR-IOR-15007007
Enrollment
Unknown
Registered
2015-09-02
Start date
2013-01-01
Completion date
Unknown
Last updated
2017-04-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Esophageal carcinoma

Interventions

sevoflurane group:sevoflurane
Control group:propofol
Group MP:methylprednisolone

Sponsors

The Second Affiliated Hospital of Shandong University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
65 Years to 75 Years

Inclusion criteria

Inclusion criteria: American Society of Anesthesiologists (ASA) physical status I, II or III; a sufficient level of education to be capable of completing neuropsychological tests; a pre-operative mini mental state examination (MMSE) score >=23; no evidence of cardiovascular, respiratory or central nervous system disease; normal renal and hepatic function; no serious hearing or visual impairment; absence of a history of benzodiazepine or antidepressant use, alcohol or cigarette misuse or drug dependence; and no contraindication to propofol or inhalational anesthesia.

Exclusion criteria

Exclusion criteria: Alzheimer's disease, a family history of mental illness or mental illness, a cognitive impairment of the disease, a history of alcohol and drug dependence

Design outcomes

Primary

MeasureTime frame
IL-6;TNF-alpha;S100-beta;—

Countries

China

Contacts

Public ContactQiao Yong
feishi_xin@126.com+86 18853110660

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Mar 15, 2026