Coronary Heart Disease
Conditions
Interventions
Huoxue Group:Taohongsiwu granules
Liqi Group:Xuefuzhuyu without Taohongsiwu granules
Liqi Huoxue Group:Xuefuzhuyu granules
Sponsors
Chinese PLA General Hospital
Eligibility
Sex/Gender
All
Age
40 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. Meeting the diagnosis of coronary heart disease; 2. Patients with qi stagnation and blood stasis syndrome by TCM as follws: Main symptoms: Chest pain and chest tightness. Accompanying symptoms: fullness in chest and hypochondrium, palpitations, dark purple tongue and uneven pulse; 3. Age: 40-60 years old; 4. I-II Cardiac function (NYHA cardiac functional grading); 5. Subjects was informed and signed informed consent voluntarily.
Exclusion criteria
Exclusion criteria: 1. Renal insufficiency: serum creatinine>2.5mg/dl (>220umo/l) in male or >2.0mg/dl (>175umo/l) in famale; 2. Significant liver disease, or ALT, AST three times higher than the upper limit of normal reference value; 3. Systolic blood pressure>160mmHg or diastolic blood pressure>100mmHg after controlling (patients need to sit for at least 5 minutes before the measurement of blood pressure); 4. Random blood glucose>=13.7mmol/L in patients with diabetes or glycated hemoglobin>=9.5%; 5. Pregnancy or women preparing for pregnant, breastfeeding women and the persons allergic to the known ingredients of the study drugs; 6. Patients combined with acute cerebrovascular disease; 7. Patients with malignant or life expectancy less than 3 years; 8. Patients with severe disease of hematopoietic system; 9. Severe mental illness; 10. Pateints who has participated or are participating in other clinical trials in three months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| TCM symptom classification quantitative score;Depression Scale;End Point;Resting ECG;Gasotransmitters;ATP in serum;Circulating non-coding RNA;Vasoactive peptide;Microvascular function; | — |
Secondary
| Measure | Time frame |
|---|---|
| Echocardiography;BNP;RAAS;CRP;Homocysteine;CD62P;Thromboelastography;Routine blood test;Routine urine test;Routine stool test;Liver and kidney function;Coagulation function; | — |
Countries
China
Contacts
Public ContactXiuhua Liu
Outcome results
None listed