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The effect and security of high doses of spironolactone in protecting residual renal function of maintenance hemodialysis patients

The effect and security of high doses of spironolactone in protecting residual renal function of maintenance hemodialysis patients

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR-IOR-15006906
Enrollment
Unknown
Registered
2015-08-03
Start date
2015-09-01
Completion date
Unknown
Last updated
2017-04-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

uremia

Interventions

The experimental group:spironolactone
The control group:Placebo

Sponsors

Nephrology department of the first affiliated hospital of chengdu medical college
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: Sixty maintenance hemodialysis patients with residual renal function meet ing the following requirements: 1. 24h urine volume >200ml; 2. Regular hemodialysis (three times a week); 3. Grade II or III heart function; 4. Review the laboratory indicators every three months regularly; 5. More than four weeks of hemodialysis and two weeks of keeping the dry weight; 6. The levels of serum potassium are below 5.0mmol/l for more than three times four weeks before entering the experiment; 7. Sign the informed consent.

Exclusion criteria

Exclusion criteria: With severe cardiovascular disease

Design outcomes

Primary

MeasureTime frame
KT/V;KRU;—

Secondary

MeasureTime frame
hemoglobin;plasma albumin;Parathyroid hormone;renin;cystatin C;—

Countries

China

Contacts

Public ContactLi Wang
93331524@qq.com+86 18080025670

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026