Chronic Obstructive Pulmonary Disease
Conditions
Interventions
Sponsors
Eligibility
Inclusion criteria
Inclusion criteria: 1. Diagnosis of chronic obstructive pulmonary disease; 2. Aged between 18 and 65 years; 3. Sign the informed consent.
Exclusion criteria
Exclusion criteria: 1. An acute exacerbation of COPD within the last 4 weeks; 2. FEV1<30% predicted; 3. Patients with tuberculosis and tumor; 4. Patients with serious primary diseases of the cardiovascular, liver, kidney, and hematological system; 5. Musculoskeletal or nervous system disease that can hinder the exercise training; 6. Mentally or legally disabled patients; 7. Patients had participated in formal exercise training in the previous 1 year.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| the St George's respiratory questionnaire; | — |
Secondary
| Measure | Time frame |
|---|---|
| the modified British Medical Research Council (mMRC);COPD Assessment Test;spirometry test;6 Minute Walk Test;Hospital Anxiety and Depression Scale;Berg Balance Scale;inflammatory markers (IL-6, CRP, IL-8, TNF-alpha);cellular immunity markers (CD4+, CD8+, CD4+/CD8+);Exacerbations per year; | — |
Countries
China