hyperalgesia
Conditions
Interventions
Control group 1:Induction of anesthesia: Remifentanil, sevoflurane, cisatracurium, Postoperative analgesia with sufentanil, tropisetron
Treatment group 1:Induction of anesthesia: Remifentanil, sevoflurane, cisatracurium, low-dose naloxone, Postoperative analgesia with sufentanil, tropisetron, low-dose naloxone
Control group 2:Induction of anesthesia: Remifentanil, sevoflurane, cisatracurium, Maintenance of anesthesia: Remifentanil, sevoflurane, Postoperative analgesia with fentanil, tropisetron
Treatment group 2:Induction of anesthesia: Remifentanil, sevoflurane, cisatracurium, low-dose naloxone, Maintenance of anesthesia: Remifentanil, sevoflurane, low-dose naloxone, Postoperative analgesia
Control group 3:After the success of subarachnoid block, continuous intravenous infusion of remifentanil. Postoperative analgesia with sufentanil, tropisetron.
Treatment group 3:After the success of subarachnoid block, continuous intravenous infusion of remifentanil and low-dose naloxone. Postoperative analgesia with sufentanil, tropisetron, low-dose naloxon
Sponsors
Beijing Military General Hospital
Eligibility
Sex/Gender
All
Age
5 Years to 50 Years
Inclusion criteria
Inclusion criteria: Cholecystectomy patients and lower extremity fracture patients aged 18 to 65 years old, hydronephrosis (and hernia) pediatric patients aged 5 to 12 years old.
Exclusion criteria
Exclusion criteria: 1. Long-term use of analgesic drugs, sedatives, antidepressants and psychotropic drugs; 2. patients suffering from severe heart disease, chronic pain, drug addicts, drug allergies; 3. patients who do not agree with experiment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| pain threshold;Pain Visual analog scale;Opioid consumption;Opioid side effects; | — |
Countries
China
Contacts
Public ContactYa-qun Ma
Outcome results
None listed