Type 2 diabetes
Conditions
Interventions
Treatment group:Gegen qinlian Decoction (granules)
placebo group:placebo
Healthy control group:none
control group of T2DM without damp-heat syndrome of intestinal:none
Sponsors
Guang’anmen Hospital,China Academy of Chinese Medicine Sciences
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. T2DM with damp-heat syndrome of intestinal: (1) signed the informed consent; (2) conforms the 1999 WHO criteria of type 2 diabetes mellitus. After screening period (diet control and exercise therapy after 2 weeks), FBG>=7.0mmol/L, but =11.1mmol/L; (3) HbA1c>=7.0%; (4) damp-heat syndrome of intestinal according to TCM syndrome differentiation; (5) aged 30-65. 2. healthy persons: (1) aged 30-65; (2) the normal constitution according to TCM criteria; (3) BMI in 18-24kg/m2; (4) no abnormal in the health examination. 3. T2DM without damp-heat syndrome of intestinal: without damp-heat syndrome of intestinal according to TCM syndrome differentiation; the rest is the same as item 1.
Exclusion criteria
Exclusion criteria: 1. Previously on diabetic therapy (including other traditional Chinese medicine and Western medicine, physical therapy, psychological therapy and health food, etc.) for up to 6 months above, group 1 month before the use of hypoglycemic, lipid-lowering drug therapy; 2. Diabetic complications, or other serious disease; 3. Blood pressure cannot be well controlled; dosage and types of antihypertensive drugs cannot remain stable; 4. In the last month, patients who had ketoacidosis, lactic acidosis, hyperosmotic coma and other acute complications of diabetesas well as infection; 5. Women who were in pregnancy or in lactation; and patients suffered from mental disease; Patients who were allergic to ingredients of Chinese drugs; 6. Patients who participated in other clinical studies 1 month before attending the study; 7. Alcohol and / or psychoactive substances, drug abusers and addicts in the past 5 years; 8. Patients who were unwilling to cooperate (unable to control the diet and take drug according to regulations, thus influencing the therapeutic effect); 9. Patients who had dysfunction of the liver and kidney; 10. Hypoglycemia.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| HbA1c;TCM Syndrome; | — |
Secondary
| Measure | Time frame |
|---|---|
| Insulin secretion (0h, 1h, 2h);Lipids (CHO, TG, HDL-c, LDL-c);waist;weight;hip;Fasting blood glucose;2 - hr plasma glucose; | — |
Countries
China
Contacts
Public ContactXiaolin Tong
Outcome results
None listed