Diabetic foot
Conditions
Interventions
NPWT group:negative pressue wound therapy
Conventional gauze therapy group:Conventional gauze therapy
Sponsors
Department of Endocrinology, Bethune international peace hospital of PLA
Eligibility
Sex/Gender
All
Age
50 Years to 70 Years
Inclusion criteria
Inclusion criteria: The inclusion criteria: patients with chronic nonhealing diabetic foot wound for more than 1 month, age range of 50–70 years old, ankle-brachial index of 0.5–0.8, transcutaneous oxygen pressure of 20–40 mmHg, and Wagner grade of 2–4. Part of the subject specimens in this clinical trial come from my previous clinical trial which also involved in the mechanism of negative pressue wound therapy on diabetic wound healing. The registration number is ChiCTR-TRC-13003399. The ethics reports, research proposals and informed consent have been submitted.
Exclusion criteria
Exclusion criteria: Exclusion criteria were as following: patients with untreated cellulitis, malignancy in the foot wound, significant necrotic tissue and osteomyelitis as well as patients with a history of treatment with growth factors or hyperbaric oxygen therapy within 30 days prior to or during the study period.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| a-SMA;Type ? collegan;Type ? collegan;EDA-Fn;Fibronectin;TGF beta 1;RhoA;ROCK; | — |
Countries
China
Contacts
Public ContactLv-yun Zhu
Outcome results
None listed