severe septic children
Conditions
Interventions
Standard dose CoQ10 group:conventional treatment + coenzyme Q10 0.6 m/kg. D, Once, 7-10d
High doses of CoQ10 group:conventional treatment + coenzyme Q10 6 m/kg. D, Once, 7-10d
control group:conventional treatment
Sponsors
Department of Critical Care Medicine of Children's Hospital Affiliated toThe Capital Institute of Pediatrics
Eligibility
Sex/Gender
All
Age
1 Years to 12 Years
Inclusion criteria
Inclusion criteria: Severe sepsis in standard: in accordance with the Chinese medical association in 2006 pediatric emergency committee recommended draft of diagnosis and treatment of pediatric septic shock SIRS + infection the diagnosis of sepsis), associated with acute respiratory distress syndrome (ARDS) or circular function disorder. This research content close to the children and parents and signed informed consent, and promised to stick to the clinical observation and related inspection
Exclusion criteria
Exclusion criteria: Children with severe sepsis is to eliminate any which were as follows: chronic heart, lung, gastrointestinal tract, blood, cancer, endocrine, congenital metabolic basis of disease, long-term daily use of immunosuppressants; Congenital acquired immunodeficiency disease of children; Above moderate malnutrition; Not signed informed consent will be; In group 1 month before using adenosine, ATP, coenzyme Q10 and other preparations or simulation; Don't want to or cannot perform inspection requirement; Coenzyme Q10 allergies.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| the serum concentrations of CoQ10;the activity of mitochondrial complexes I+III;pyruvate concentration;pyruvate concentration; | — |
Countries
China
Contacts
Public ContactZhang QI
Outcome results
None listed