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The effect of propofol before sputum aspiration on intracranial pressure and prognosis in patient with severe neurologic deficiency

The effect of propofol before sputum aspiration on intracranial pressure and prognosis in patient with severe neurologic deficiency

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR-IOR-15006441
Enrollment
Unknown
Registered
2015-05-16
Start date
1990-01-01
Completion date
Unknown
Last updated
2017-04-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cerebral vascular disease and severe brain injury

Interventions

Control group:Routine management
Observation group:The injection of propofol before sputum aspiration was 0.5-1mg/kg

Sponsors

West China Hospital,Sichuan university
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 75 Years

Inclusion criteria

Inclusion criteria: Paitent with cerebrovascular disease and severe craniocerebral injury, supported with ventilator and ICP monitor; aged 18 to 75 years old; stable circulation; voluntary participation, and signed the informed consent.

Exclusion criteria

Exclusion criteria: The patients with insufficient blood volume, unstable circulation, hypotension, shock, and pregnant women

Design outcomes

Primary

MeasureTime frame
ICP peak;ICP peak time;ICP stable value after sputum aspiration;ICP steady recovery time needed;The maximum respiratory rate within 5 minutes after sputum suction;Maximum heart rate within 5 minutes after sputum aspiration;The highest blood pressure within 5 minutes after smoking;Minimum Oxygen saturation of 1 minutes after suction;Maximum Oxygen saturation of 5 minutes after suction;Cough response grading;Sputum suction effect;ventilation time;GOS score;—

Countries

China

Contacts

Public ContactMenghang Wu
wumh1126@126.com+86 18980602145

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 25, 2026