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A study on acupuncture treatment modulating brain functional networks and metabolism of differences TCM syndrome types in depression

A study on acupuncture treatment modulating brain functional networks and metabolism of differences TCM syndrome types in depression

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR-IOR-15006357
Enrollment
Unknown
Registered
2015-05-05
Start date
2015-05-20
Completion date
Unknown
Last updated
2017-04-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

depressive disorder

Interventions

Liver qi stagnation group:electroacupuncture stimulation
stagnated QI transforming into fire group:electroacupuncture stimulation
heart-spleen deficiency group:electroacupuncture stimulation
Healthy subject:electroacupuncture stimulation

Sponsors

First Affiliated Hospital, Guangxi University of Chinese Medicine
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 40 Years

Inclusion criteria

Inclusion criteria: 1. Diagnostic criteria: According to the "International Classification of diseases and diagnostic criteria" (ICD-10) diagnostic criteria of depression in patients, diagnosed by a responsible treatment, for many years engaged in the clinical work of deputy director of the Department of psychology doctor. The main symptom criteria with low mood, and at least one of the following 4 items: the loss of interest, no pleasure; the energy loss or fatigue; the psychomotor retardation or agitation; the low self-evaluation, self blame or guilt; the Lenovo difficulties or consciously thinking ability; the recurring idea to die or suicide; and sleep disorders such as insomnia, wake up early, or sleep too much; the loss of appetite or significant weight loss; 9 hyposexuality; 2. the severity of the standarde standard According to Hamilton Depression Scale (HAMD) score of 24, according to Davis JM line: Grade 1 (mild depression): HAMD score in the 20 to 26 points, is always melancholy and moody inattention, slow speech, and sorrow; grade 2 (moderate depression): HAMD score of 27 to 34, anxiety emotion unstable, disheveled, and on their own, speech content less pain urgency decline; 3. TCM diagnostic criteria and classification of syndrome differentiation TCM syndrome diagnosis and treatment standard according to the State Administration of traditional Chinese Medicine published in 2002". TCM diagnosis of depression, because of emotional discomfort, qi stagnation and disease with depression anxiety, good mood restless or irritable, tears in. Differentiation is divided into 3 main groups of TCM syndromes: Qi Stagnation: depression, chest or abdominal distension, swelling, heating frequency, deep sigh, menstruation No, the tongue coating thin white, pulse string; the Qi fire type: irritability, chest tightness, flank pain, headache, red mouth, mouth pain, noisy pantothenic acid, constipation, yellow urine, red tongue, yellow moss, pulse a few strings; the deficiency of two: good thoughts seem puzzled, heart palpitations, insomnia, forgetfulness, sallow complexion, dizziness, fatigue, easy to sweat, no pleasure in eating, pale tongue, thin white fur, pulse string or breakdown; 4. inclusion criteria To meet the above criteria; the first onset; the age ranged from 18 to 40 years old, the examination and treatment; the subjects were right-handed.

Exclusion criteria

Exclusion criteria: Exclusion criteria: The combined with other mental disorders, alcohol or drug dependent patients; the suffering from severe physical disease, recently there have been serious infection or undergo surgery; the pregnant or lactating women; the patients with severe depression, HAMD score more than 35 points, a suicide; the other in clinical drug research; the needle feeling evaluation no response to acupuncture and acupuncture; all patients with contraindications and smoking history. Cases of standard: Not treated in accordance with the regulations, to judge the curative effect, or incomplete information affect the efficacy and safety evaluation. The intolerant to acupuncture treatment.

Design outcomes

Primary

MeasureTime frame
Amplitude of low frequency fluctions;regional homogeneity;functional connection;5-hydroxy tryptamine;Magnetic resonance spectroscopy;

Countries

China

Contacts

Public ContactDemao Deng
ddemao@163.com+86 13507880885

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026