Allogeneic hematopoietic stem cell transplantation patients with hematologic malignancies or non-hematologic malignancies
Conditions
Interventions
MSCs group :patients received 4 cycles umbilical cord-derived MSCs (1*10^7 per month) from 4 to 7 months after transplantation
normal saline group :Patients received 4 cycles normal saline(100ml per month) from 4 to 7 months after transplantation
Sponsors
Department of Hematology, Xinqiao Hospital, Third Military Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1.Allogeneic HSCT patients did not occured cGVHD; 2.age between 18 to 60; 3.KPS score > 60; 4.No serious organ dysfunction; 5.Expected survival >3 months.
Exclusion criteria
Exclusion criteria: 1.Have serious organ dysfunction; 2.Combined with other cancer need treatment; 3.Presence of clinical signs of brain dysfunction or severe mental illness can not understand or comply with the study protocol; 4.Can not scheduled follow-up; 5.Can not guarantee the completion of the treatment plan and the necessary follow-up observation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Chronic graft versus host disease; | — |
Secondary
| Measure | Time frame |
|---|---|
| relapse;Overall survival;Disease free survival;Lymphocyte subset; | — |
Countries
China
Contacts
Public ContactXi Zhang
Outcome results
None listed