one-lung ventilation
Conditions
Interventions
Dexmedetomidine 3:Dexmedetomidine 0.3 ug/kg/h
Dexmedetomidine 5:Dexmedetomidine 0.5ug/kg/h
Dexmedetomidine7:Dexmedetomidine0.7ug/kg/h
Sponsors
Wuxi People's Hospital, Jiangsu Province
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. aged from 18 to 80 years; 2. with written agreement of the participants; 3. need general anesthesia; 4. need one-lung ventilation; 5. planned to used dexmedetomidine as sedation and analgesia.
Exclusion criteria
Exclusion criteria: 1. combined with chronic lung disease such as chronic obstructive pulmonary disease, lung tuberculosis, lung abscess, lung fibrosis, bronchiectasis, pulmonary emphysema and so on; 2. combined with heart disease such as valve disease, congenital heart disease, coronary heart disease, arrythmia and so on; 3. pregnant or breast-feeding women, planned to pregnant or breast-feeding women during the study; 4. dexmedetomidine allergy; 5. bradycardia or reduced sinoatrial node function; 6. tracheal dysplasia or anatomic variation; 7. participants who participated any clinical drug trial 90 days before recruiting; 8. with history of lung operation; 9. pneumothorax; 10. general connective tissure diseases or severe autoimmune disease; 11. participants with known or suspected bad compliance such as alcoholic, drug dependence or mental disease; 12. hematologic system disease or poor control diabetes; 13. predict to effect the efficacy and safety evaluation of the participants with combined drug use during the study; 14. with bad lung function before operation such as partial pressure of oxygen less than 60 mmHg.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| blood gas analysis; | — |
Countries
China
Contacts
Public ContactGu Zhengfeng
Outcome results
None listed