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Methoxamine and Combining Methoxamine with Atropine Infusion to Maintain Blood Pressure During Spinal Anesthesia for Cesarean Delivery

Methoxamine and Combining Methoxamine with Atropine Infusion to Maintain Blood Pressure During Spinal Anesthesia for Cesarean Delivery

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR-IOR-15006170
Enrollment
Unknown
Registered
2015-03-28
Start date
2015-04-01
Completion date
Unknown
Last updated
2017-04-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

spinal anesthesia hypotension for cesarean section

Interventions

Group M:received a 2-mL bolus of methoxamine (containing methoxamine 2 mg)
Group MA1:received 2-mL bolus of methoxamine + atropine (containing methoxamine 2mg and atropine 0.1mg)
group MA2:received a 2-mL bolus of methoxamine + atropine (containing methoxamine 2mg and atropine 0.2mg)
group MA3:received a 2-mL bolus of methoxamine + atropine (containing methoxamine 2mg and atropine 0.3mg)

Sponsors

Renmin hospital, Shiyan
Lead Sponsor

Eligibility

Sex/Gender
Female

Inclusion criteria

Inclusion criteria: ASA I-II women with singleton pregnancies scheduled for elective caesarean delivery under spinal anaesthesia were recruited in this randomised and double-blind study.

Exclusion criteria

Exclusion criteria: Subjects were excluded if they had pre-existing or pregnancy-induced hypertension, diabetes mellitus, known cardiovascular or cerebrovascular disease, fetal abnormality, or contraindication to spinal anaesthesia. The subjects that did not develop hypotension (systolic blood pressure <=80% of baseline) and did not require vasopressors were excluded from the study and the randomization code was not broken and further subjects were recruited.

Design outcomes

Primary

MeasureTime frame
Blood pressure;heart rate;Apgar scores;Umbilical arterial pH;Umbilical arterial PO2;Umbilical arterial PCO2;Umbilical arterial Base excess;

Countries

China

Contacts

Public ContactXingjun Luo
gswsydlxj@163.com+86 13636261628

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026