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The comparative analysis of different propofol target-controlled infusion models used in anesthetic induction and maintainance

The Effective Effect-Site Propofol Concentration for Induction and LMA Insertion with Three Pharmacokinetic Models in Gynaecologic Patients

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR-IOR-15005965
Enrollment
Unknown
Registered
2015-01-20
Start date
2015-03-01
Completion date
Unknown
Last updated
2017-04-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Gynaecologic Disease

Interventions

M1 group:original Marsh model
M2 group:modified Marsh model
S group:Schnider model

Sponsors

Peking Union Medical College Hospital
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
20 Years to 65 Years

Inclusion criteria

Inclusion criteria: 1. ASA physical status I~II grade; 2. Age: 20~65 years; 3. Elective gynecological lower abdomen open surgery or perineal surgery.

Exclusion criteria

Exclusion criteria: 1. Morbidly obese patients with BMI=30 kg/m2; 2. Dyslipidemia; 3. Long term use of sedative-hypnotic drugs or opioids before surgery; 4. Complicated with central nervous system diseases; 5. Difficulty in communication; 6. Suspected difficult airway; 7. known allergy to propofol or any other ingredients in the emulsion.

Design outcomes

Primary

MeasureTime frame
movement;—

Secondary

MeasureTime frame
blood pressure;heart rate;NT;—

Countries

China

Contacts

Public ContactXiuhua Zhang
xiuzhangpumch@aliyun.com+86 10 69152020

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026