Mild clinical Alzheimer’s disease
Conditions
Interventions
Two groups:Physical exercise and Working memory training versus either physical exercise (PE) training, working memory (WM) training, combined PE-WM training, or caregiver education in six weeks inter
Sponsors
Department of Psychiatry, The Chinese University of Hong Kong
Eligibility
Sex/Gender
All
Age
60 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1. Subjects from 60 to 90 years old; 2. DSM-5 diagnosis of Major Neurocognitive Disorder due to AD (22), which would satisfy the criteria for significant cognitive decline in at least one of six areas of cognition (memory, perceptual-motor, complex attention, language, executive function and social cognition) and functional disturbance, with clinical or biological features indicative of AD; 3. CDR of 1 indicating mild dementia; and 4. Ambulatory with low risk of fall as assessed by the physiotherapist (co-A).
Exclusion criteria
Exclusion criteria: 1. Past history of bipolar affective disorder or psychosis; 2. Physical frailty affecting attendance to training sessions; 3. Already attending regular cognitive training; 4. History of major neurological deficit including history of stroke, or traumatic brain injury; and 5. Significant communicative impairments.
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| Clinical Dementia Rating (CDR);Working memory test;Memory and language tests;changes in neuropsychiatric symptoms across;The Disability Assessment for Dementia (DAD);Subjective sense of exertion;Quality of Life –AD.;Leisure activity participation;adverse event; | — |
Primary
| Measure | Time frame |
|---|---|
| Global cognitive function; | — |
Countries
China
Contacts
Public ContactProf. Linda CW Lam
Outcome results
None listed